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Medicinal and Life Sciences
Experimental and Clinical Pharmacy
Affiliate Graduate School
Educational Research Center for Clinical Pharmacy

Medicinal and Life Sciences

Department	Research topics
Organic and Medicinal Chemistry (Hidehiko Nakagawa, Ph.D., Professor)	Molecular design, synthesis, and evaluation of biologically functional and useful compounds Development of the methods for exploration and analysis for bioactive substances like medical leads based on chemical approach Bioorganic chemistry for reactive oxygen species and nitric oxide Development of the compounds for controlling cellular properties based on photochemistry and organic chemistry
Bioorganic-inorganic Chemistry (Naoki Umezawa, Ph.D., Professor)	Creation of functional molecules useful for elucidating biological functions Rational design and synthesis of pharmaceutical lead compounds Development of functional molecules based on new concepts Development of technologies to achieve drug discovery using medium-sized molecules (e.g., peptides)
Synthetic Organic Chemistry (Seiichi Nakamura, Ph.D., Professor)	Studies on the Synthesis of Biologically Active Natural Products Development of Efficient Methods for Construction of Molecular Architectures Development of Novel Asymmetric Reactions
Synthetic Supramolecular Chemistry (Shin-ichi Ikeda, Ph.D., Associate Professor)	Development of New Organic Reaction Using Transition-Metal Catalysts Analysis of Molecular Recognition by Computational Chemstry
Multilevel Biofunctional Analytics (Hirokazu Yagi, Ph.D., Professor)	Elucidation of biomolecular networks through omics analyses and their application to drug discovery Elucidation of glycoprotein biosynthesis and mechanisms of glycan modification Elucidation of the molecular mechanisms regulating cell differentiation and functional development in the nervous and immune systems
Physical Chemistry of Colloid and Polymer (Tohru Okuzono, Ph.D., Associate Professor) (Akiko Toyotama, Ph.D., Associate Professor)	Phase transition and phase separation of colloids Theoretical and numerical study of nonequilibrium soft matter Development of novel photonic colloidal materials Crystallization of charged colloids under microgravity
Molecular Biology (Michiko Shirane, Ph.D., Professor)	Organelle biology Neurological diseases Signal transduction
Drug Delivery and Nano Pharmaceutics (Tetsuya Ozeki, Ph.D., Professor)	DDS for Brain Tumor Therapy Nanoparticles DDS for Inhalation Therapy of Tuberculosis DDS for Regeneration Medication of Bone Tissue DDS for Malaria Therapy Nanoparticles for Water-insoluble Drugs
Structural Biology and Biomolecular Engineering (Koichi Kato, Ph.D., Professor)	Structural Glycobiology Protein Sociology Structural Immunology NMR Structural Biology and Protein X-ray Crystallography Structure-based Biomolecular Engineering

Experimental and Clinical Pharmacy

Department	Research topics
Pharmacognosy (Toshiaki Makino, Ph.D., Professor)	Clinical and Experimental Pharmacology of Kampo Medicines Molecular & Cellular Biology of Plant Secondary Metabolism Natural Product Chemistry using Endogenous Bacteria Quality Control for Natural Medicaments
Molecular and Cellular Health Sciences (Shigeaki Hida, Ph.D., Professor)	Role of interleukins in immune and inflammatory reactions Host defense mechanism against Mycobacterium tuberculosis Etiological role of cigarette smoking in rheumatoid arthritis Immune evasion mechanisms by microorganisms
Biological Chemistry (Shin-ichi Hoshino, Ph.D., Professor)	Mechanism of mRNA Decay in Eukaryotes Posttranscriptional Regulation of Gene Expression Mechanism of mRNA Quality Control (Surveillance) Roles of eRF3 Family G Proteins in the Regulation of mRNA Decay
Molecular and Cellular Pharmacology (Hisao Yamamura, Ph.D., Professor)	Molecular Functions of Ion Channels and Related Diseases / Channelopathy Bioimaging of Cellular Ion Dynamics and Ion Channel Molecules Discovery of Drugs acting on Ion Channels and Screening System
Biomedical Science (Mitsuharu Hattori, Ph.D., Professor)	Molecular mechanism of brain development Molecular mechanism of neuronal shape formation Understanding how human brain works Exploring novel lipid signaling in neuronal cells
Biopharmaceutics (Tomoya Yasujima, Ph.D., Associate Professor)	Functions and Regulation Mechanisms of Transporters Involved in Drug Disposition Roles of Transporters in Drug Disposition Physiological and Pathophysiological Roles of Transporters Methodologies of Evaluation and Prediction of Drug Disposition
Molecular, Cellular Pathobiology and Therapeutics (Mineyoshi Aoyama, Ph.D.,M.D., Professor)	Molecular Mechanism of Atherosclerosis Pathobiology of Thrombosis and Development of New Therapeutics Analysis of Pathophysiological Roles of Sphingolipids in the Development of Cardiovascular and Metabolic Syndromes Cellular Mechanism of Wound Healing and Development of New Therapeutics
Cell Signalling (Yasumichi Inoue, Ph.D., Professor)	Stressors and Lifestyle Related Disease Cellular Stress and Regulation of Cell Growth, Apoptosis and Differentiation Development of Molecular Target Therapy of Cancer Drug Metabolism in Pathological Conditions Development of Experimental Models to Reconstitute Drug Metabolism and Toxicity in Human
Neuropharmacology (Kazuhiko Kume, M.D., Ph.D., Professor)	Sleep and Circadian rhythm studies using Drosophila melanogaster Establishment of effective treatment of neuropathic pain Prevention and treatment of undesirable effect of the drugs Establishment of effective treatment of metabolic syndrome.
Clinical Pharmacy (Takahiro Iwao, Ph.D., Professor)	Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients Mechanism of Diabetes Vascular Endothelium Dysfunction Development of Continuing Education Program for Pharmacists
Hospital Pharmacy (Yuji Hotta, Ph.D., Associate Professor)	Lower urinary symptoms Acute and chronic kidney disease Male sexual dysfunction Congenital metabolic disorders Clinical research
Regulatory Science (Hiroshi Arakawa, Ph.D., Professor)	Construction and development of biomimetic models for drug safety assessment Drug side effects and drug-drug interactions via drug transporters Elucidation of mechanisms involved in pharmacokinetics and safety using clinical data Elucidation of dynamics and physiological effects of uremic toxins

Affiliate Graduate School

Department	Research topics
Oncology (Masahiro Aoki, M.D., Professor (Division of Pathophysiology, Aichi Cancer Center Research Institute))	Clarifying the roles of tumor microenvironment in cancer progression Elucidating the molecular mechanisms of metastasis Unraveling the pathophysiology of cancer cachexia Elucidating the molecular mechanisms of exosome biogenesis Elucidating the spatial regulation of oncogenic signaling via lipid rafts Clarifying the roles of microRNA in cancer progression
Experimental Gerontology (Koichi Iijima, Ph. D., Professor (Department of Alzheimer's Disease Research, Center for Development of Advanced Medicine for Dementia))	Mechanisms underlying Alzheimer's disease (AD) pathogenesis Identification of genetic risk factors of AD Development of therapeutic strategy for AD Endocytosis and axonal transport defects in AD
Pharmaceutical Quality Science (Ken-ichi Izutsu, Ph.D., Professor (Division of Cell-Based Therapeutic Products, National Institute of Health Sciences))
Integrative Science for Dynamic Living Systems (Kazuhiro Aoki, Ph.D., Professor (Quantitative Biology Group, National Institutes of Natural Sciences))	Live cell imaging and quantification of cell cycle and apoptosis Optogenetic manipulation of intracellular signal transduction Whole brain imaging in C. elegans Development of new molecular dynamics simulation algorithm Molecular dynamics simulation of protein aggregates and amyloid fibrils
Regulatory Science for Evaluation of Pharmaceuticals and Medical Devices (Tomoko Ohsawa, Ph.D., Professor (Pharmaceuticals and Medical Devices Agency))	PMDA Pharmaceuticals Medical devices Safety triangle Regulatory science

Educational Research Center for Clinical Pharmacy

Department	Research topics
Clinical Pharmacy (Tadashi Suzuki, Ph.D., Professor)	Differentiation of Human iPS Cells into Hepatocytes and Small Intestinal Epithelial Cells Establishment of Gisease Specific iPS Cells from Inherited Metabolic Disease Patients Mechanism of Diabetes Vascular Endothelium Dysfunction Development of Continuing Education Program for Pharmacists

Research Groups